The ABRomics project aims at developing an online community-driven platform to scale up and improve surveillance and research on antibiotic resistance from a One Health perspective. The integration and analysis of omics data with associated metadata requires the development of databases accessible to the community, the automatic use of standard pipelines for genomic and metagenomic data analysis, and the development of new bioinformatics and mathematical methods to answer generic and specific research questions related to AMR. There is also a need to develop a user-friendly Web interfaces for data deposit and for the presentation and retrieval of results.